Cal Griffith practices in the area of intellectual property, including patents, trademarks, copyrights, trade secrets, unfair competition, and related antitrust law. The litigation matters he has worked on include a patent infringement action brought by client DePuy Spine against Medtronic resulting in an award of $179 million for DePuy Spine; other patent infringement actions brought by DePuy resulting in awards of $52 million and $26 million; a patent infringement action brought by Martek Biosciences against Lonza concerning omega-3 fatty acids for use as food additives resulting in a jury verdict for Martek; the defense of a nine-patent action against client Brush/Williams Advanced Materials, resulting in a favorable settlement for Brush; an arbitration between Eastman Kodak Company and Cetus Corporation over rights in polymerase chain reaction (PCR) technology; the defense of patent infringement actions brought against The Procter & Gamble Company with regard to disposable diaper products, laundry detergents, and other consumer products; a patent infringement action brought by Molten Metal Equipment against Metaullics; the defense of patent infringement actions against Lamson & Sessions concerning electrical outlet products; the defense of a patent action brought against The Firestone Tire & Rubber Co. involving a tire tread patent; employee unfair competition and trade secret cases for Premier Farnell (formerly Premier Industrial Corporation); and a patent infringement action brought by client International Paper against the largest manufacturer of plastic laminates in the United States.

Cal has been recognized as one of the country's leading intellectual property lawyers in Chambers USA, The Best Lawyers in America, and Ohio Super Lawyers.